NVidia control panel can help solve issues and improve performance with 3D applications. However, it has some lazy bugs in it like graying out the “remove” application button in “Manage 3D settings”.
You do not need to download anything like random driver cleanup programs to get rid of this. You can do it with “regedit”.
Start up regedit.
Either click start and type “regedit” or go to the run box and put it in there.
Once you are in the Registry Editor be careful and do not delete anything unless you are sure. It will not prompt you to make sure an the wrong thing can ruins your Windows install.
Search (CTRL + F, or Edit… Search) for “NvCplAppNamesStored”.
It ought to be the only entry (see below):
The HKEY is below for power-users.
In the panel on the right, find what you do not want, select it (check it is the correct one) and press the delete key.
Exit Registry Editor and exit NVidia Control Panel.
NVidia have kindly made the Control Panel restart automatically so you will not have to do it.
Check your Manage 3D Settings and the entry will be gone.